Neural circuitry of panic

Anxiety | Agoraphobia | Panic Attacks

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The amygdala has a crucial role as an anxiety way-station that mediates incoming stimuli from the environment (thalamus and sensory cortex) and stored experience (frontal cortex and hippocampus; dark arrows), which affects the anxiety and panic response by stimulating various brain areas responsible for key panic symptoms (red arrows).The periaqeductal gray in the midbrain could be especially important for mediating panic-anxiety. Drug treatments can target all parts of this system, aff ecting amygdala and frontal-lobe interpretation of stimuli, or output effects. Cognitive-behavioural treatment aff ects the frontal-lobe areas, especially in the medial prefrontal cortex, which is known to inhibit input to the amygdale by using a braking action.

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